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All Journal International Journal of Public Health Science (IJPHS) SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jambi Medical Journal "Jurnal Kedokteran dan Kesehatan" Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Indonesian Journal of Biotechnology INDONESIAN JOURNAL OF PHARMACY Jurnal Keperawatan Padjadjaran
Rebriarina Hapsari
Department Of Microbiology, Faculty Of Medicine, Diponegoro University, Semarang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Journal of Biomedicine and Translational Research

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Diagnostic value of SARS-CoV-2 RDT-Ab with RT-PCR: Secondary data at Diponegoro National Hospital Muhammad Thifan Satyagraha; Nani Maharani; Rebriarina Hapsari; Meita Hendrianingtyas
Journal of Biomedicine and Translational Research Vol 8, No 1 (2022): April 2022
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v1i1.13759

Abstract

Background: The SARS-CoV-2 rapid diagnostic test antibody (RDT-Ab) was most often used as an early detection tool for COVID-19 at the beginning of pandemic. Whereas the antibody response was formed in the second week after the onset of symptoms.Objective: To evaluate the diagnostic value of the SARS-CoV-2 RDT-Ab, including sensitivity (Se), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (PLR), and negative likelihood ratio (NLR), in patients at Diponegoro National Hospital, Semarang, Indonesia.Methods: Data subjects have been selected retrospectively using purposive sampling based on inclusion criteria (patients who had shortness of breath, pneumonia, suspected, possible, or confirmed COVID-19, and data on the results of the SARS-CoV-2 RDT-Ab IgM and/or IgG (Leccurate® SARS-CoV-2 Antibody Rapid Test Kit) with a valid RT-PCR as gold standard) and exclusion criteria (patients who only had one of either SARS-CoV-2 RDT-Ab or RT-PCR). Researchers analyzed the diagnostic value of SARS-CoV-2 RDT-Ab with RT-PCR which gave the possibility of true-positive, false-positive, true-negative, and false-negative results arranged in a 2x2 table. According to WHO, the diagnostic value is said to be good at least having a sensitivity value of 80% and specificity of 97%.Results: The diagnostic value of SARS-CoV-2 RDT-Ab with RT-PCR, which was evaluated from 1142 patients retrospectively, included IgM (Se 65.25%, Sp 89.51%, PPV 46.70%, NPV 94.81%, PLR 6.22, NLR 0.39), IgG (Se 58.16%, Sp 93.01%, PPV 53.95%, NPV 94.04%, PLR 8.32, NLR 0.45), IgM and IgG (Se 53.90%, Sp 94.21%, PPV 56.72%, NPV 93.55%, PLR 9.30, NLR 0.49), IgM and/or IgG (Se 69.50%, Sp 88.31%, PPV 45.58%, NPV 95.36%, PLR 5.95, NLR 0.35).Conclusion: SARS-CoV-2 RDT-Ab (Leccurate® SARS-CoV-2 Antibody Rapid Test Kit) is not ideal to be used as a rapid diagnostic test for COVID-19.Keywords: COVID-19, Rapid diagnostic test, RT-PCR, SARS-CoV-2 antibody
Co-Authors Alfi Dian Uly Noor Anjarwati, Dwi Utami Anugrah Riansari Benediktus Yohan Dionisius Denis Edi Dharmana Failasuf Wibisono Firdaus, Nadilla Shafa Fitria Endah Janitra Helmia Farida Indah Sri Wahyuningsih Ira Anggar Kusuma Jonathan Alvin Nugraha Halim Maria Estela Karolina Maryani Maryani Masfiyah Masfiyah, Masfiyah Meita Hendrianingtyas Muhammad Mahfud Muhammad Thifan Satyagraha Mujahidah Mujahidah Mujahidah, Mujahidah Nahwa Arkhaesi Nani Maharani Nuryastuti, Titik R. Tedjo Sasmono Rahayu Rahayu Sarinti Sarinti Setiawati, Setiawati Sotianingsih Haryanto Stefanie Natalia Halim Subakir Subakir Thania Lathifatunnisa Putri Agusti Tri Nur Kristina V. Rizke Ciptaningtyas Winarto Winarto